Start with 500mg once daily for the first week to minimise GI side effects, then increase to 500mg with each main meal (1000–1500mg total daily, split across 2–3 doses). Take with food to maximise GLP-1 release and reduce stomach upset. Split dosing is essential because berberine has a short half-life.

Take 500–1000mg daily (standardised to 50%+ EGCG) with breakfast or before exercise. Avoid evening doses due to caffeine content. Take with food to reduce nausea. If you're sensitive to stimulants, choose a decaffeinated extract.

Take 1g (1000mg) with a large glass of water (at least 250ml) 30–60 minutes before each main meal. This can be done once, twice, or three times daily depending on your appetite and schedule. CRITICAL: Always take with adequate water — never swallow dry or without liquid, as it can cause oesophageal obstruction.

Take 200–1000mcg daily with meals. The 1000mcg dose showed the strongest results in trials, but start at 200–400mcg for the first week to assess tolerance, then increase if needed. Can be taken once daily or split across meals. Pairs particularly well with berberine for synergistic metabolic support.