Interaction Checker
Add your supplements and medications below to check for potential interactions. Free, instant, and evidence-based.
Your Supplements
Your Medications
(optional)Common medications:
Major Interactions to Know
The most important supplement-drug interactions in our database
Omega-3 Fish Oil + Warfarin (blood thinners)
Fish oil has antiplatelet effects that may increase bleeding risk with anticoagulants.
Consult your doctor before combining. INR monitoring recommended.
Iron + Levothyroxine (thyroid medication)
Iron significantly reduces absorption of thyroid medication.
Take at least 4 hours apart.
Berberine + Metformin (diabetes medication)
Both lower blood sugar. Combined use may cause dangerous hypoglycemia.
Do not combine without medical supervision.
Vitamin K2 + Warfarin (blood thinners)
Vitamin K directly opposes warfarin's anticoagulant effect.
Requires careful INR monitoring and physician oversight.
Turmeric / Curcumin + Warfarin, Aspirin (blood thinners)
Curcumin has antiplatelet properties that increase bleeding risk.
Avoid high doses if on blood thinners.
CoQ10 + Warfarin (blood thinners)
CoQ10 is structurally similar to vitamin K and may reduce warfarin effectiveness.
INR monitoring is essential if combining.
This is not an exhaustive list. Use the checker tool above to test your specific combination, and always consult your GP or pharmacist before changing your supplement or medication routine.
Frequently Asked Questions
Can I take magnesium with blood pressure medication?
Magnesium can enhance the effects of blood pressure medications (antihypertensives), potentially causing blood pressure to drop too low. This is a moderate interaction. Monitor your blood pressure regularly and consult your GP before combining.
Is it safe to take fish oil with warfarin?
This is a major interaction. Omega-3 fish oil has antiplatelet effects and may increase bleeding risk when combined with warfarin or other anticoagulants. Always consult your doctor before combining fish oil with blood thinners.
Can I take iron supplements with thyroid medication?
Iron significantly reduces absorption of levothyroxine (thyroid medication). This is a major interaction. Take iron at least 4 hours apart from your thyroid medication.
Does turmeric interact with blood thinners?
Yes, this is a major interaction. Curcumin (the active compound in turmeric) has antiplatelet properties and may increase bleeding risk when combined with warfarin, aspirin, or other blood-thinning medications.
Can I take berberine with metformin?
This is a major interaction. Both berberine and metformin lower blood sugar. Combined use may cause dangerous hypoglycemia (blood sugar dropping too low). Do not combine without medical supervision.
Is vitamin K2 safe with warfarin?
No — this is a major interaction. Vitamin K directly opposes the anticoagulant effect of warfarin. Any vitamin K supplementation (including K2) requires careful INR monitoring and physician oversight.
Can ashwagandha interact with my medications?
Ashwagandha may interact with thyroid medications (it can increase thyroid hormone levels), sedatives and benzodiazepines (additive drowsiness), and immunosuppressants (it stimulates the immune system). These are moderate interactions — consult your GP before combining.
How does the SuppUp interaction checker work?
Our tool cross-references your selected supplements and medications against a database of 67+ clinically documented interactions across 31 supplements. Interactions are classified as major (avoid combination), moderate (use with caution), or minor (generally safe, be aware). The data is sourced from clinical research and Australian therapeutic guidelines.