Lion's Mane (Hericium erinaceus) is a medicinal mushroom with strong evidence for supporting nerve growth and cognitive function. It contains unique compounds — hericenones and erinacines — that stimulate Nerve Growth Factor (NGF) production, which is essential for neuron maintenance and repair. Used for centuries in traditional Chinese medicine, modern clinical trials show improvements in mild cognitive impairment, memory, and focus.
How it works
Hericenones (from fruiting body) and erinacines (from mycelium) cross the blood-brain barrier and stimulate synthesis of Nerve Growth Factor (NGF). NGF promotes neuronal growth, maintenance, and myelination. Beta-glucans in the fruiting body also modulate immune function via macrophage and NK cell activation.
Evidence-based uses
Studies show improved cognitive function and nerve growth factor stimulation.
Clinical Evidence
Lions Mane supplementation significantly improved cognitive function scores at weeks 8, 12, and 16 compared to placebo.
Lion's Mane contains beta-glucans that stimulate innate immune function. Animal and in vitro studies show enhanced macrophage and NK cell activity. The polysaccharides in the fruiting body have demonstrated immunomodulating properties. Human clinical evidence is limited but mechanistic support is strong.
Safety
Lions Mane may lower blood sugar levels. Monitor glucose if taking diabetes medication.
Lions Mane may have mild antiplatelet properties. Use caution if on anticoagulant therapy and monitor for signs of bleeding.
Compare prices
3 products compared across Australian retailers. Sorted by price per serve.
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| Product | Price | /serve | |
|---|---|---|---|
Best Real Mushrooms Lions Mane Extract 120 Capsules iHerb | $34.99 | $0.29 | |
Real Mushrooms Real Mushrooms Lion's Mane 120 Caps iHerb | $49.95 | $0.42 | |
Thorne Lions Mane 60 Capsules Thorne | $44.99 | $0.75 |
Prices in AUD. Some links are affiliate links — we may earn a commission at no extra cost to you.
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Lions Mane has 2 known interactions. Check if it's safe with your medications.
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This information is for educational purposes only and is not intended as medical advice. Always consult a healthcare professional before starting any supplement. Evidence ratings are based on peer-reviewed clinical research. Individual results may vary.