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Amino Acid

Glycine

Simplest amino acid with wide-ranging benefits for sleep, collagen synthesis, and cognitive function. Excellent safety profile even at high doses.

Powder, Capsule|Sleep, Skin Health|From $0.06/serve

How it works

Mechanism of Action

Acts as an inhibitory neurotransmitter promoting relaxation. Essential building block for collagen (33% of collagen is glycine). Supports glutathione synthesis and bile acid conjugation.

Evidence-based uses

What Glycine Is Used For

Sleep

Lowers core body temperature and acts on NMDA receptors to promote sleep. Very safe even at high doses. May improve sleep quality without next-day grogginess.

Moderate
3g/day
Take 3g approximately 1 hour before bed. Can dissolve in water (slightly sweet taste).
1-2 weeks

Clinical Evidence

The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus (2015)RCT0

Glycine 3g before bed improved subjective sleep quality, reduced sleep latency, and decreased daytime sleepiness. Mechanism involves lowering core body temperature via peripheral vasodilation.

Glycine ingestion improves subjective sleep quality in human volunteers (2006)RCT · n=11

Subjects taking 3g glycine before bed reported significantly improved sleep satisfaction, reduced daytime drowsiness, and improved cognitive function next day.

Skin Health

Essential building block of collagen (every third amino acid). Supplementing supports endogenous collagen synthesis.

Moderate
5-10g/day
Split across meals or take as a single dose. Mix powder into drinks.
8-12 weeks

Clinical Evidence

Glycine supplementation in recovery from musculoskeletal and skin injuries (2019)Review0

Glycine as a collagen precursor (every 3rd amino acid in collagen) supports wound healing and skin repair when supplemented alongside vitamin C.

Compare prices

Buy Glycine in Australia

5 products compared across Australian retailers. Sorted by price per serve.

ProductPrice/serve
Best

BulkSupplements

BulkSupplements Glycine Powder

BulkSupplements

$18.90$0.06Buy

Thorne

Thorne Glycine

Thorne

$28.00$0.11Buy

Life Extension

Life Extension Glycine 1000mg

Life Extension

$12.00$0.12Buy

NOW Foods

NOW Glycine 1000mg

iHerb

$12.90$0.13Buy

Source Naturals

Source Naturals Glycine Powder

Amazon AU

$22.50$0.14Buy

Prices in AUD. Some links are affiliate links — we may earn a commission at no extra cost to you.

Should you take Glycine?

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This information is for educational purposes only and is not intended as medical advice. Always consult a healthcare professional before starting any supplement. Evidence ratings are based on peer-reviewed clinical research. Individual results may vary.